Automated pupillometry addresses the limitations of manual pupillary examinations, and is recommended by the Resuscitation Council UK in their 2025 guidelines, for neuroprognostication of out-of-hospital cardiac arrest (OHCA) patients.
An estimated 115,000 OHCA occur in the UK each year, with low survival often linked to poor neurological outcomes and withdrawal of life-sustaining treatment (WLST).
Neurological examination is central to prognostication, with the Pupillary Light Reflex (PLR) a key assessment. Traditionally examined manually with a pen torch, the PLR is recognised by European and UK Resuscitation 2025 guidelines as highly subjective and affected by sedatives and opioids commonly used in OHCA care.
The Neurological Pupil Index (NPi), measured by the NeurOptics NPi-300 Pupillometer, provides an objective, quantitative assessment largely unaffected by medications such as Midazolam, Remifentanil, Fentanyl, Propofol, and Dexmedetomidine.
Automated pupillometry with the NPi-300 delivers reliable neuroprognostic information at 72 hours, in line with RCUK guidelines.
